Mode of Delivery Shapes Gut Colonization Pattern and Modulates Regulatory Immunity in Mice
نویسندگان
چکیده
منابع مشابه
Mode of delivery shapes gut colonization pattern and modulates regulatory immunity in mice.
Delivery mode has been associated with long-term changes in gut microbiota composition and more recently also with changes in the immune system. This has further been suggested to link Cesarean section (C-section) with an increased risk for development of immune-mediated diseases such as type 1 diabetes. In this study, we demonstrate that both C-section and cross-fostering with a genetically di...
متن کاملMode of delivery - effects on gut microbiota and humoral immunity.
BACKGROUND The rate of caesarean deliveries has increased 10-fold worldwide during the past decades. OBJECTIVE To evaluate differences in the establishment of gut microbiota in infants born by vaginal or caesarean delivery and its impact on mucosal immunity. METHODS Altogether, 165 consecutive children, prospectively followed from birth at our clinic in Turku, Finland, were gathered; 141 (8...
متن کاملMode of delivery and gut microbiota
In 1985 the World Health Organization (WHO) stated: “There is no justification for any region to have Caesarean Section (CS) rates higher than 10-15%”[1]. During the last decades the percentage of births managed by CS has increased beyond the recommended level, especially in high income areas such as Italy, Germany, France, United Kingdom, and North America [2,3]. Emerging evidences indicate th...
متن کاملThe mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review
BACKGROUND The human gut is the habitat for diverse and dynamic microbial ecosystem. The human microbiota plays a critical role in functions that sustain health and is a positive asset in host defenses. Establishment of the human intestinal microbiota during infancy may be influenced by multiple factors including delivery mode. Present review compiles existing evidences on the effect of deliver...
متن کاملMetabolome progression during early gut microbial colonization of gnotobiotic mice
The microbiome has been implicated directly in host health, especially host metabolic processes and development of immune responses. These are particularly important in infants where the gut first begins being colonized, and such processes may be modeled in mice. In this investigation we follow longitudinally the urine metabolome of ex-germ-free mice, which are colonized with two bacterial spec...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2014
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1400085